Res Sq. 2020 Apr 27:rs.3.rs-25639. doi: 10.21203/rs.3.rs-25639/v1. Preprint.

ABSTRACT

Coronavirus infection is associated to life-threatening respiratory failure. The aryl hydrocarbon receptor (AHR) was recently identified as a host factor for Zika and dengue viruses; AHR antagonists decrease viral titers and ameliorate ZIKV-induced pathology in vivo. Here we report that AHR is activated during coronavirus infection, impacting anti-viral immunity and lung basal cells associated to tissue repair. Hence, AHR antagonists are candidate therapeutics for the management of coronavirus-infected patients.

PMID:32702728 | PMC:PMC7336521 | DOI:10.21203/rs.3.rs-25639/v1

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