In much of the West, including Brazil, drug use has increased since social distancing began due to the pandemic. Use of smoked and modified drugs, and their impacts on health, may contribute to aggravate the pandemic. However, studies on the relationship between use of smoked drug and the new coronavirus are still scarce and have not received enough attention in global health recommendations. This paper aimed to briefly review the relationship between use of smoked drugs and acute respiratory syndrome coronavirus 2 [SARS-CoV-2]. Recent studies also suggest that drug consumption increases the risk of contamination by SARS-CoV-2 and leads to worse prognosis, particularly drugs that affect lung functions. Use of smoked drugs, especially tobacco, is strongly associated with lung diseases that are risk factors for contamination by SARS-CoV-2. It is essential to develop strategies based on specific characteristics of drug users and for mental health professionals to be part of strategic teams. It is also necessary to invest in information campaigns regarding risks and prevention of harm caused by smoked drugs, as well as to design strategies that facilitate access to psychosocial treatment during the pandemic.